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In this landmark work, the author team led by Dr. Sean Carroll presents the general principles of the genetic basis of morphological change through a synthesis of evolutionary biology with genetics and embryology. In this extensively revised second edition, the authors delve into the latest discoveries, incorporating new coverage of comparative genomics, molecular evolution of regulatory proteins and elements, and microevolution of animal development.
- An accessible text, focusing on the most well-known genes, developmental processes and taxa.
- Builds logically from developmental genetics and regulatory mechanisms to evolution at different genetic morphological levels.
- Adds major insights from recent genome studies, new evo-devo biology research findings, and a new chapter on models of variation and divergence among closely related species.
- Provides in-depth focus on key concepts through well-developed case studies.
- Features clear, 4-color illustrations and photographs, chapter summaries, references and a glossary.
- Presents the research of Dr. Carroll, a pioneer in the field and the past president of the Society for Developmental Biology.
An Instructor manual CD-ROM for this title is available. Please contact our Higher Education team at HigherEducation@wiley.com for more information.
- Sales Rank: #826585 in Books
- Brand: Brand: Wiley-Blackwell
- Published on: 2004
- Original language: English
- Number of items: 1
- Dimensions: 9.70" h x .60" w x 7.50" l, 1.45 pounds
- Binding: Paperback
- 268 pages
- Used Book in Good Condition
Review
Sean Carroll, author of one of the books under review and a coauthor of another, has made important contributions to the understanding of evolution and development. From DNA to Diversity, written with two other scientists, is the second edition of a book that has become a classic for students of evolution."
The New York Review of Books, Volume LIII, Number 8
"With almost poetic ease, the authors tell a highly complex story without distorting its scientific substance. The story line goes through the levels of biological hierarchy all the way to the details of gene regulation and emerges with a deeper understanding of biological diversity. In Sean Carroll developmental evolution has found its Darwin."
Gunter Wagner, Yale University
"This book will be an excellent introductory text, exciting newcomers to the field, be they students in biology, or experts in either evolutionary biology or embryology who want to gain an appreciation for the insights developmental genetics is providing into the evolution of animal diversity."
Cliff Tabin, Harvard University Medical School
"From DNA to Diversity is written for a general audience, including undergraduates, with an interest in developmental and evolutionary biology, and it is a joy to read. Using striking examples, the authors summarize the current state of thinking on the interconnectedness between developmental genetics and evolutionary diversification."
Axel Meyer, University of Konstanz; Nature
"This book helps to fill a gap in the teaching of evolutionary theory that arose because developmental biology was not a direct participant in the evolutionary synthesis….This is an outstanding account of the latest findings in molecular developmental biology."
James W. Valentine, Professor Emeritus, University of California, Berkeley
"The authors have done an excellent job of distilling the large and complex literature on molecular genetics that is pertinent to understanding how gene networks evolve... The writing is consistently clear, concise, and engaging. "
Gregory A. Wray, Duke University; Science
"Carroll, Weatherbee, and Grenier have produced a wonderful and exciting introduction to the field of evolutionary developmental biology....Newcomers and aficionados will find this a compelling read."
Martin J. Cohn, University of Florida; Evolution and Development
"...this is one book that everybody should read who wants to know why 'evo-devo' is such a hot topic right now."
Manfred Laubichler, Arizona State University
"From DNA to Diversity can be, and should be read by College and University students as well as scientists out of the field, who want to be informed of what is new and promising in biology."
Jean Deutsch, Universite Phillippe et Marie Curie, Paris; BioEssays
"An engaging style, clear, four-colour illustrations, and up-to-date content all combine to make this text a highly accessible and definitive synthesis of the field."
Ethology, Ecology and Evolution
“This highly technical textbook facilitates learning by its conversational tone, summarization of important points [and] exciting case studies…Beautifully illustrated… this book is a pleasure to read.”
Southeastern Naturalist
From the Back Cover
Animals diverge from common ancestry through changes in their DNA, but what are the genes that control morphology? In this landmark work, the author team led by Dr. Sean Carroll presents the general principles of the genetic basis of morphological change through a synthesis of evolutionary biology with genetics and embryology. The text first addresses the history of animal evolution, model system developmental genetics, and genetic regulatory mechanisms, and then examines case studies of evolutionary change at different genetic and morphological levels.
In this extensively revised second edition, the authors delve into the latest discoveries, incorporating new coverage of comparative genomics, molecular evolution of regulatory proteins and elements, and microevolution of animal development. This new edition also includes major insights from recent genome studies, incorporates new findings from evo-devo biology research, and adds a new chapter focusing on models of variation and divergence among closely related species.
An engaging style, clear, four-color illustrations, and up-to-date content all combine to make this text a highly accessible and definitive synthesis of the field.
About the Author
Sean B. Carroll is currently an investigator of the Howard Hughes Medical Institute and Professor of Molecular Biology and Genetics at the University of Wisconsin. His research for the past twenty years has focused on the genetics of animal development and evolution, and yielded many original discoveries as to the mechanisms underlying the making and evolution of animal form.
Jennifer K. Grenier is currently a senior scientist in the Microarray Group at Mirus Corporation in Madison, Wisconsin. Her scientific interests include the evolution of development, comparative genomics, and innovative technologies for functional genomics research.
Scott D. Weatherbee is a research fellow at the Memorial Sloan Kettering Cancer Center in New York City. He studies the developmental genetics of limb formation and patterning.
Most helpful customer reviews
15 of 15 people found the following review helpful.
Evo-Devo For The Graduate Student
By The Spinozanator
We have about 25,000 genes. Some of these are "tool kit" genes that we share with all other animals. They evolved well before the Cambrian explosion over 540 million years ago from a bilaterally symmetrical common ancestor. Almost exact counterparts are found in apes and mice, and close counterparts in arthropods and worms. Next to most genes is a stretch of so-called "junk DNA" that does not code for genes. These DNA segments contain from three to twenty (or more) switches that collectively turn that gene on or off. The switches are activated or repressed by the differing concentration gradients of the protein products of other genes produced by neighboring cells. By virtue of the servo-feedback loops creating unique combinations of the protein products of tool kit genes, cells of the early embryo create a geographical map of their future body.
An escalating orchestra of domino effects builds complexity, each new development affecting the others. The tool kit genes and the other core genes that control biochemical function from bacteria to man are resistant to mutation. Novelty and speciation comes from the infinite variety of changes that come from the readily mutable genetic switches - allowing for changes in a segment without mortally wounding the rest of the animal. Not a single biologist 40 years ago would have predicted these discoveries.
The exciting developments of evo-devo have sent jolts of electricity through the evolutionary community. Nothing basic has been overturned; much has been enhanced. For example: It used to be thought that eyes had evolved independently many, many times - after all, the lumps of light sensitivity in primitive wormlike creatures, the compound eyes of insects, and the eyes of mammals have more differences than commonalities. As it turns out, the making of each eye-like organ is directed by a PAX6 tool kit gene. Not only that, if the PAX6 gene from the mouse is artificially introduced into the genetic material destined for the leg of the fly, an eye will form on the fly leg...and it's not a mouse eye - it's a fly eye. The mouse PAX6 gene switches - influenced by chemical gradients from adjacent tissue in the fly embryo - cause the gene to produce a fly eye! Astounding!
Tool kit genes (and other genes) are frequently named after the anomaly that doesn't develop when that gene is absent. The TINMAN gene controls development of the heart and circulatory system from butterflies to badgers - named after the Wizard of Oz character who had no heart. The wealth of information presented in this book will surprise, educate, and entertain the reader - and evo-devo researchers have just scratched the surface. New graduates in biology are surging into this explosive and previously neglected science.
There are three other books that I know of that cover these captivating discoveries of the last 30 years:
"Coming to Life," by Christiane Nusslein-Volhard. This fine book, written by a Nobel Prize winner for her meticulous ground-breaking work on fruit flies emphasizes the concentration gradients, which are indeed central to the story.
"The Plausibility of Life," by Kirschner and Gerhart. These authors are so excited about the new findings, they think it deserves a name - facilitated variation - and of course, they thought of the name. It is an excellent book with more basic sciences than the book under review, emphasizing how evo-devo facilitates novelty through an enhanced Baldwin Effect.
"Endless Forms Most Beautiful," also by Sean B. Carroll, written more for the college graduate who has taken a little biology.
I have studied them all. For the general public, "Endless Forms Most Beautiful" is the best. For those more familiar with molecular biochemistry and genetics, "DNA to Diversity" contains much more specific information - although anyone who would like one book would like the other.
"From DNA to Diversity" is a superbly written book -essential reading for the advanced reader who wishes to keep up with the stunning advances that have occurred in evolutionary knowledge during the past thirty years.
35 of 36 people found the following review helpful.
Which Evo-Devo Book for You?
By Edward F. Strasser
High School, College, Grad School? This book is at the grad school level. Carroll has also written Endless Forms Most Beautiful at the college level and The Making of the Fittest at the high school level. (You can check on "Read all my reviews" to read more about these.)
My own background is this: My formal education in biology consisted of an introductory course in college 40-odd years ago. Since then I've read a lot and in the last two years I've had a very strong interest in molecular and evolutionary biology. (For more info, click on my name, above. My Profile also has a link to my Listmania list of evolution books. Note that you don't have to be a grad student to read this book.)
I read From DNA to Diversity first and it was too much for me. I then read Endless Forms. That was pretty understandable, so I went back to Diversity and found it reasonable clear. I have since read it a third time and I am very fond of it.
Of the thousands of genes involved in the early development of animals, this book concentrates on a few, along with the proteins with which they interact and the various body parts they affect. Special attention is paid to the Hox genes and their insect homologues. Because these have large-scale effects in development, changes in them and in their regulation have profound effects on evolution. I especially enjoyed the section where Carroll combined many bits of information to show us the basic features that must have been present in the first bilaterally symmetric animal, that tiny but promising ancestor of us all. This is one of the bonuses we get for making the extra effort to read the grad-level book.
I find the text very clear and the overall organization - starting with the workings of the major toolkit genes, proceeding through descriptions of how those genes direct the overall shaping of the animal, and on to general considerations of evolution -- proceeds nicely.
[2 June 2007: This was one of the first reviews I wrote and I have added bits as my skills have improved. It got to be a bit patchy, so I have just finished a mafor revision.]
54 of 55 people found the following review helpful.
Wonderful intro to evo-devo
By DR P. Dash
This is a short (about 200 pages)book, but it really is a fantastic introduction to evolutionary developmental biology. I've had an (amateurish) interest in this for awhile, and Carroll et al really clarify basic principles in the field. It is beautifully illustrated...full color diagrams and photos on almost every page. The basic concept is that there is a limited set of genes (the "toolkit") that control development and evolution throughout the animal kingdom. The basic function of these genes--like the hox genes, sonic hedgehog, ubx, and so forth--is clearly explained, and examples of the evolution of their function by changes in their own, and their target genes, cis-regulatory binding sites are shown. In depth coverage is given naturally to the fruit fly, but other insects also, and this is contrasted to the situation in vertebrate development. A real pleasure to read! Anybody with a college course or two in biology should find it comprehensible. I am absolutely positive this field is going to explode in the coming years, and I am certain that this book will be an inspiration for those who will become involved in it. If you're at all interested in the subject of the molecular mechanisms of evolution...don't hesitate to get this book!
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